Antibacterial and biodegradable bandage with exudate absorption and smart monitoring for chronic wound management

Zhaochuan Yu; Hao Wu; Xing Zhang; Yang Jiang; Chao Liu; Yuqian Liu; Farzad Seidi; Chao Deng

doi:10.1016/j.jobab.2025.06.001

Volume 10 Issue 3

Aug. 2025

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Article Navigation > Journal of Bioresources and Bioproducts > 2025 > 10(3): 373-385

Zhaochuan Yu, Hao Wu, Xing Zhang, Yang Jiang, Chao Liu, Yuqian Liu, Farzad Seidi, Chao Deng. Antibacterial and biodegradable bandage with exudate absorption and smart monitoring for chronic wound management[J]. Journal of Bioresources and Bioproducts, 2025, 10(3): 373-385. doi: 10.1016/j.jobab.2025.06.001

Citation:

Zhaochuan Yu, Hao Wu, Xing Zhang, Yang Jiang, Chao Liu, Yuqian Liu, Farzad Seidi, Chao Deng. Antibacterial and biodegradable bandage with exudate absorption and smart monitoring for chronic wound management[J]. Journal of Bioresources and Bioproducts, 2025, 10(3): 373-385. doi: 10.1016/j.jobab.2025.06.001

Citation:

Zhaochuan Yu, Hao Wu, Xing Zhang, Yang Jiang, Chao Liu, Yuqian Liu, Farzad Seidi, Chao Deng. Antibacterial and biodegradable bandage with exudate absorption and smart monitoring for chronic wound management[J]. Journal of Bioresources and Bioproducts, 2025, 10(3): 373-385. doi: 10.1016/j.jobab.2025.06.001

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Antibacterial and biodegradable bandage with exudate absorption and smart monitoring for chronic wound management

doi: 10.1016/j.jobab.2025.06.001

Zhaochuan Yu^a,
Hao Wu^{b
,
,},
Xing Zhang^d,
Yang Jiang^e,
Chao Liu^a,
Yuqian Liu^a,
Farzad Seidi^a,
Chao Deng^{a, c
,
,}

a.
International Innovation Center for Forest Chemicals and Materials and Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, China
b.
School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing 211166, China
c.
Macromolecular Chemistry and Bavarian Polymer Institute, University of Bayreuth, Bayreuth 95440, Germany
d.
College of Textile and Fashion, Hunan Institute of Engineering, Xiangtan 411104, China
e.
College of Textiles and Clothing, Qingdao University, Qingdao 266071, China

More Information

Corresponding author: E-mail address: wuhao0902@njmu.edu.cn (H. Wu); E-mail address: chao.deng@uni-bayreuth.de (C. Deng)
Received Date: 2025-03-12
Accepted Date: 2025-05-21
Rev Recd Date: 2025-05-14

Available Online: 2025-06-08

Publish Date: 2025-08-01

Abstract

Abstract

Despite the promising potential of smart bandages in wound care, the lack of effective integration among infection control, exudate management, and real-time wound monitoring remains a major obstacle in clinical application. Herein, neomycin (NEO)-grafted cellulose-based nonwovens (CNs) were used as the antibacterial network and blueberry extract (anthocyanin, AC) as the colorimetric additive to create the excellent dual network gel (DNG) bandage for smart bandages along with a polyvinyl alcohol/cellulose nanofiber (PVA/CNFs) matrix. The aerogel bandage loaded with AC demonstrates a pH-sensitive color-changing response and high-efficiency free radical scavenging ability (all greater than 93.61%), enabling the in-situ monitoring of wound healing and inhibiting wound inflammation, while the nonwoven network grafted with NEO endows the aerogel composites with excellent antibacterial properties (>99% against Staphylococcus aureus and Escherichia coli). In vivo evaluation using a S. aureus-infected full-thickness wound model in mice demonstrated that the DNG bandage significantly accelerated wound healing and improved tissue regeneration, outperforming commercial dressings. Furthermore, upon absorbing exudate, the aerogel converts into a hydrogel, providing efficient fluid absorption and preventing wound re-contamination, thereby achieving dynamic exudate management. Evidently, the DNG smart bandage is a promising management tool for the synergistic treatment of persistent wounds and introduces a fresh strategy for medical regenerative medicine.
- Smart bandage,
- Cellulosic nonwovens,
- Antibacterial,
- Self-negative pressure,
- Wound monitoring

Declaration of competing interest
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Supplementary materials
Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.jobab.2025.06.001.
Peer review under the responsibility of Editorial Office of Journal of Bioresources and Bioproducts.

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