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Production of Itaconic Acid Through Microbiological Fermentation of Inexpensive Materials

  • Corresponding author: Jianchun JIANG, bio-energy@163.com
  • Received Date: 2019-03-10
    Fund Project:

    The research was supported by Natural Science Found-ation of Jiangsu Province of China (No. BK20160150).

  • Itaconic acid (IA) is a precursor of various chemicals, which has been on the US Department of Energy's list of the top 12 platform chemicals that can potentially be produced from biomass. The IA is mainly produced through a bio-fermentation method with sugar as raw material. However, the high cost and low yield restrict the industrial application of the IA. This review summarized research advances in the IA production from alternative substrates. In particular, the types of substrates as well as existing problems in the IA fermentation, strain breeding, and process regulation were discussed. And it is pointed that decreasing the price of the IA with alternative substrates and increasing the titer through genetic engineering should be further focused on to support the industrialization of the IA. Keywords:itaconic acid; fermentation; Aspergillus terreus; biomass
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Production of Itaconic Acid Through Microbiological Fermentation of Inexpensive Materials

    Corresponding author: Jianchun JIANG, bio-energy@163.com
  • 1 Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry;National Engineering Laboratory for Biomass Chemical Utilization;Key and Open Laboratory of Forest Chemical Engineering, State Forestry Administration;Key Laboratory of Biomass Energy and Material, Jiangsu Province;Nanjing 210042, China;
  • 2 Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, China
Fund Project:  The research was supported by Natural Science Found-ation of Jiangsu Province of China (No. BK20160150).

Abstract: Itaconic acid (IA) is a precursor of various chemicals, which has been on the US Department of Energy's list of the top 12 platform chemicals that can potentially be produced from biomass. The IA is mainly produced through a bio-fermentation method with sugar as raw material. However, the high cost and low yield restrict the industrial application of the IA. This review summarized research advances in the IA production from alternative substrates. In particular, the types of substrates as well as existing problems in the IA fermentation, strain breeding, and process regulation were discussed. And it is pointed that decreasing the price of the IA with alternative substrates and increasing the titer through genetic engineering should be further focused on to support the industrialization of the IA. Keywords:itaconic acid; fermentation; Aspergillus terreus; biomass

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