Volume 1 Issue 1
Feb.  2016
Turn off MathJax
Article Contents
Yanpeng Liu, Jianshu Li. Advances of cyclodextrin polymers for the delivery of biotech drugs[J]. Journal of Bioresources and Bioproducts, 2016, 1(1): 7-17. doi: 10.21967/jbb.v1i1.38
Citation: Yanpeng Liu, Jianshu Li. Advances of cyclodextrin polymers for the delivery of biotech drugs[J]. Journal of Bioresources and Bioproducts, 2016, 1(1): 7-17. doi: 10.21967/jbb.v1i1.38

Advances of cyclodextrin polymers for the delivery of biotech drugs

doi: 10.21967/jbb.v1i1.38
Funds:

Financial support from the National Natural Science Foundation of China (Grant No. 21534008, 51322303, and 51573110) and State Key Laboratory of Polymer Materials Engineering (sklpme2014-3-01) are gratefully acknowledged.

  • Currently, biological drugs such as gene, protein, and monoclonal antibody are widely applied in the clinic due to their excellent effectiveness. However, they still have some problems, including poor solubility, instability, toxicity, and weak capability to cross cell membranes. Owing to the specific structure of cyclodextrins (CDs) and the advantage of polymeric backbones, various cyclodextrin polymers (CDPs) have been designed as delivery systems for biotech drugs. In this review, after a brief introduction on CDPs and discussion of their physicochemical and biological properties, we will focus on recent advances in the use of CDPs for the delivery of biotech drugs. This review highlights the structure-function relationship of CDPs to their performance in biotech drug delivery. Finally, an outlook will be proposed on the developing trends and challenge in this field.

     

  • loading
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1197) PDF downloads(18) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return