Volume 11 Issue 1
Feb.  2026
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Article Navigation >  Journal of Bioresources and Bioproducts  > 2026  >  11(1): 100224
Hao Wang, Pengyu He, Guoliang Tang, Fuyu Qi, Xu Lu, Maoxu Zhang, Ruizhu Zheng, Xiaohong Li, Zhijun Shi, Yaopeng Zhang, Guang Yang. Skin repairing procedure inspired polypyrrole/bacterial cellulose/platelet rich plasma composite hydrogel as diabetes wound dressing[J]. Journal of Bioresources and Bioproducts, 2026, 11(1): 100224. doi: 10.1016/j.jobab.2025.10.004
Citation: Hao Wang, Pengyu He, Guoliang Tang, Fuyu Qi, Xu Lu, Maoxu Zhang, Ruizhu Zheng, Xiaohong Li, Zhijun Shi, Yaopeng Zhang, Guang Yang. Skin repairing procedure inspired polypyrrole/bacterial cellulose/platelet rich plasma composite hydrogel as diabetes wound dressing[J]. Journal of Bioresources and Bioproducts, 2026, 11(1): 100224. doi: 10.1016/j.jobab.2025.10.004
shu

Skin repairing procedure inspired polypyrrole/bacterial cellulose/platelet rich plasma composite hydrogel as diabetes wound dressing

doi: 10.1016/j.jobab.2025.10.004
  • a.

    Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China

  • b.

    State Key Laboratory of Advanced Fiber Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China

  • c.

    State Key Laboratory of New Textile Materials and Advanced Processing Technologies, Wuhan Textile University, Wuhan 430200, China

  • d.

    Organ Transplantation Clinical Medical Research Center of Hubei Province, Wuhan 430030, China

More Information
  • Corresponding author: E-mail address: shizhijun@hust.edu.cn (Z. Shi); E-mail address: zyp@dhu.edu.cn (Y. Zhang); E-mail address: gyang-hust@hust.edu.cn (G. Yang)
  • Received Date: 2025-07-02
  • Accepted Date: 2025-09-23
  • Rev Recd Date: 2025-09-13
    • Available Online: 2025-11-03
  • Publish Date: 2026-02-01
    Abstract
  • Diabetic ulcers represent a kind of severe chronic wound that presents significant challenges to global healthcare systems. The impaired healing process in diabetic wounds is attributed to persistent inflammation, compromised angiogenesis, and bacterial infections. When dermic injury occurs, the skin will initiate a complex cascade of natural repair procedures to facilitate coordinated progression through inflammatory, proliferative, and remodelling phases. Inspired by these physiological repair processes, a multifunctional hydrogel dressing was designed by combining capacitive polypyrrole (PPy) with bacterial cellulose (BC) hydrogel and platelet-rich plasma (PRP) to achieve synergistic antibacterial efficacy, immunomodulation of the wound microenvironment, and enhanced tissue regeneration. The BC hydrogel serves as a scaffold for PRP encapsulation, protecting growth factors from protease degradation while enabling sustained release. Capacitive PPy not only provides potent antibacterial activity through electric field (EF) mediated charge storage, but also promotes electrical signal transduction to regulate growth factor release kinetics. In vitro results revealed that pre-charged polypyrrole/bacterial cellulose/platelet-rich plasma (PBP) composite hydrogels exhibited superior bactericidal efficacy, enhanced fibroblast and endothelial cell proliferation, and modulation of macrophage polarization. In diabetic wound models, treatment with the electroactivated PBP composite hydrogel demonstrated a marked reduction in inflammatory responses, accelerated vascular regeneration, enhanced collagen deposition, and overall improvement in wound healing.

     

    • Author contributions
    Conceptualization: Hao Wang, Pengyu He, Zhijun Shi, Yaopeng Zhang, Guang Yang. Validation and Investigation: Hao Wang, Pengyu He, Guoliang Tang, Fuyu Qi, Xu Lu, Maoxu Zhang, Ruizhu Zheng, Xiaohong Li. Data curation: Hao Wang, Pengyu He, Guoliang Tang, Fuyu Qi, Xu Lu, Maoxu Zhang, Ruizhu Zheng, Xiaohong Li, Zhijun Shi, Yaopeng Zhang, Guang Yang. Writing-original draft: Hao Wang, Pengyu He, Zhijun Shi. Writing-review and editing: Hao Wang, Pengyu He, Guoliang Tang, Fuyu Qi, Xu Lu, Maoxu Zhang, Ruizhu Zheng, Xiaohong Li, Zhijun Shi, Yaopeng Zhang, Guang Yang.
    Ethical statement
    All of the animal experiments were performed in compliance with the guidelines set by the National Research Council's Guide for the Care and Use of Laboratory Animals and were approved by the Animal Ethics Committee of Huazhong University of Science and Technology ([2023] IACUC No 3863). We followed internationally recognized ethical guidelines for animal experimentation and ensure that animals receive appropriate care and minimal suffering during the experimental process.
    Availability of data
    Data available on request from the authors.
    Declaration of competing interest
    The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
    Declaration of generative AI and AI-assisted technologies in the writing process
    During the preparation of this work, the author(s) used DeepSeek in order to improve the readability and language of the manuscript. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the published article.
    Supplementary materials
    Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.jobab.2025.10.004
    ✩ Peer review under the responsibility of Editorial Office of Journal of Bioresources and Bioproducts.
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