Functionalized microalgae as emerging composite bioproducts for biomedical applications: Design, fabrication and prospects

Yige Gao; Tao Tong; Ziyuan Zeng; Kun Hou; Dongyang Miao; Chaobo Huang; Ranhua Xiong

doi:10.1016/j.jobab.2026.100249

Volume 11 Issue 2

May 2026

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Yige Gao, Tao Tong, Ziyuan Zeng, Kun Hou, Dongyang Miao, Chaobo Huang, Ranhua Xiong. Functionalized microalgae as emerging composite bioproducts for biomedical applications: Design, fabrication and prospects[J]. Journal of Bioresources and Bioproducts, 2026, 11(2): 100249. doi: 10.1016/j.jobab.2026.100249

Citation:

Yige Gao, Tao Tong, Ziyuan Zeng, Kun Hou, Dongyang Miao, Chaobo Huang, Ranhua Xiong. Functionalized microalgae as emerging composite bioproducts for biomedical applications: Design, fabrication and prospects[J]. Journal of Bioresources and Bioproducts, 2026, 11(2): 100249. doi: 10.1016/j.jobab.2026.100249

Citation:

Yige Gao, Tao Tong, Ziyuan Zeng, Kun Hou, Dongyang Miao, Chaobo Huang, Ranhua Xiong. Functionalized microalgae as emerging composite bioproducts for biomedical applications: Design, fabrication and prospects[J]. Journal of Bioresources and Bioproducts, 2026, 11(2): 100249. doi: 10.1016/j.jobab.2026.100249

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Functionalized microalgae as emerging composite bioproducts for biomedical applications: Design, fabrication and prospects

doi: 10.1016/j.jobab.2026.100249

Yige Gao^a,
Tao Tong^a,
Ziyuan Zeng^b,
Kun Hou^a,
Dongyang Miao^{a
,
,},
Chaobo Huang^{a
,
,},
Ranhua Xiong^{a
,
,}

a State Key Laboratory for the Development and Utilization of Forest Food Resources, Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, China;
b Stem Cell and Regenerative Medicine Center, Peking University, Beijing 100191, China

Funds:

The manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript. This work was supported by National Natural Science Foundation of China (No. 22275093

52303040), Natural Science Foundation of Jiangsu Province for Distinguished Young Scholars (No. BK20230008), and Natural Science Foundation of Jiangsu Higher Education Institutions of China (No. 23KJB430025).

22275094

Received Date: 2025-12-10
Accepted Date: 2026-03-16
Rev Recd Date: 2026-03-10

Available Online: 2026-05-07

Publish Date: 2026-03-27

Abstract

Abstract

The transformation of abundant bioresources into versatile bioproducts is the cornerstone of modern bioeconomy. Microalgae are sustainable bioresources traditionally used for biofuels and food supplements. Additionally, their unique structure and physiological characteristics make them promising platforms for high-value bioproducts. While the potential of microalgae-based smart and functional materials is rapidly expanding, the direct utilization of microalgae biomass faces inherent limitations in biomedicine, including inadequate targeting specificity, suboptimal bioavailability, and limited functionality under native conditions. Therefore, the controlled assembly of microalgae with polymers, nanoparticles, and therapeutic drugs to manufacture microalgae-based composite bioproducts is critical for unlocking their potential in precise diagnosis and therapy. This review presents structural design strategies and recent applications of functionalized microalgae bioproducts in biomedical scenarios, linking functionalization strategies to performance considerations, focusing on fabricating advanced composite bioproducts from raw bioresources. Specifically, functionalized microalgae enable lesion-localization imaging, biosensing and real-time monitoring in diagnostics; promote wound healing, resist harmful substances, and address emergencies like myocardial ischemia in therapeutics; and achieve targeted drug delivery, enhanced efficacy of photodynamic, photothermal and sonodynamic therapy in theranostics. Finally, the technical and clinical translation bottlenecks of functionalized microalgae are discussed, emphasizing interdisciplinary solutions spanning bioresources to biomedicine, aiming to provide actionable insights for researchers in related fields.
- Bioresource,
- Functionalized microalgae,
- Bioproduct,
- Biomedical,
- Drug delivery,
- Wound healing

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References(156)

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