Chitosan hydrogel-stabilized red blood cell membrane interface for robust electrochemical sensing of environmental contaminants

Yusi Bu; Guoxi Xia; Minglei Zhang; Jiabo Wang; Qiuhua Chen; Guoxiang Wang; Xiaolian Shi; Fang Sui

doi:10.1016/j.jobab.2026.100283

Volume 11 Issue 4

Aug. 2026

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Yusi Bu, Guoxi Xia, Minglei Zhang, Jiabo Wang, Qiuhua Chen, Guoxiang Wang, Xiaolian Shi, Fang Sui. Chitosan hydrogel-stabilized red blood cell membrane interface for robust electrochemical sensing of environmental contaminants[J]. Journal of Bioresources and Bioproducts, 2026, 11(4): 100283. doi: 10.1016/j.jobab.2026.100283

Citation:

Yusi Bu, Guoxi Xia, Minglei Zhang, Jiabo Wang, Qiuhua Chen, Guoxiang Wang, Xiaolian Shi, Fang Sui. Chitosan hydrogel-stabilized red blood cell membrane interface for robust electrochemical sensing of environmental contaminants[J]. Journal of Bioresources and Bioproducts, 2026, 11(4): 100283. doi: 10.1016/j.jobab.2026.100283

Citation:

Yusi Bu, Guoxi Xia, Minglei Zhang, Jiabo Wang, Qiuhua Chen, Guoxiang Wang, Xiaolian Shi, Fang Sui. Chitosan hydrogel-stabilized red blood cell membrane interface for robust electrochemical sensing of environmental contaminants[J]. Journal of Bioresources and Bioproducts, 2026, 11(4): 100283. doi: 10.1016/j.jobab.2026.100283

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Chitosan hydrogel-stabilized red blood cell membrane interface for robust electrochemical sensing of environmental contaminants

doi: 10.1016/j.jobab.2026.100283

a School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China;
b Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China;
c Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China

Funds:

This work was supported by the National Natural Science Foundation of China (No. 82503461).

Received Date: 2026-02-09
Accepted Date: 2026-07-15
Rev Recd Date: 2026-06-10

Available Online: 2026-09-01

Publish Date: 2026-08-01

Abstract

Abstract

The development of robust biomimetic interfaces remains challenging due to the inherent instability of native cell membranes when integrated into functional devices. Herein, we reported a bio-based functional composite in which a chitosan-derived conductive hydrogel served as a multifunctional matrix to achieve unprecedented stabilization of red blood cell membranes (RBCMs). Leveraging the three-dimensional polycationic network and abundant amino groups of this natural polysaccharide, the hydrogel electrostatically anchored RBCMs while preserving their native fluidity and membrane-bound acetylcholinesterase conformation-overcoming a long-standing bottleneck in biomembrane-based material engineering. Integration of carboxylated multi-walled carbon nanotubes endowed the composite with efficient electron transfer capability without compromising biocompatibility. The resulting biomimetic interface retained 85.8% of its initial electrochemical response after 7 days of continuous operation and enabled sensitive detection of organophosphate pesticides in real agricultural samples (apples, oranges, and tomatoes). This work established chitosan hydrogel as a versatile bio-based platform for constructing stable biomembrane composites, expanding the application scope of natural polysaccharides in functional material design for environmental monitoring.
- Chitosan hydrogel,
- Red blood cell membrane,
- Membrane stabilization,
- Bio-based composite,
- Electrochemical biosensor

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References(47)

References

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