Volume 11 Issue 4
Aug.  2026
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Article Navigation >  Journal of Bioresources and Bioproducts  > 2026  >  11(4): 100283
Yusi Bu, Guoxi Xia, Minglei Zhang, Jiabo Wang, Qiuhua Chen, Guoxiang Wang, Xiaolian Shi, Fang Sui. Chitosan hydrogel-stabilized red blood cell membrane interface for robust electrochemical sensing of environmental contaminants[J]. Journal of Bioresources and Bioproducts, 2026, 11(4): 100283. doi: 10.1016/j.jobab.2026.100283
Citation: Yusi Bu, Guoxi Xia, Minglei Zhang, Jiabo Wang, Qiuhua Chen, Guoxiang Wang, Xiaolian Shi, Fang Sui. Chitosan hydrogel-stabilized red blood cell membrane interface for robust electrochemical sensing of environmental contaminants[J]. Journal of Bioresources and Bioproducts, 2026, 11(4): 100283. doi: 10.1016/j.jobab.2026.100283
shu

Chitosan hydrogel-stabilized red blood cell membrane interface for robust electrochemical sensing of environmental contaminants

doi: 10.1016/j.jobab.2026.100283
  • a.

    School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, China

  • b.

    Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

  • c.

    Health Science Center, Xi’an Jiaotong University, Xi’an 710061, China

More Information
  • Corresponding author: E-mail address: shxl@xjtu.edu.cn (X. Shi); E-mail address: suifang@xjtufh.edu.cn (F. Sui)
  • Received Date: 2026-02-09
  • Accepted Date: 2026-07-15
  • Rev Recd Date: 2026-06-10
    • Available Online: 2026-07-18
  • Publish Date: 2026-08-01
    Abstract

  • The development of robust biomimetic interfaces remains challenging due to the inherent instability of native cell membranes when integrated into functional devices. Herein, we reported a bio-based functional composite in which a chitosan-derived conductive hydrogel served as a multifunctional matrix to achieve unprecedented stabilization of red blood cell membranes (RBCMs). Leveraging the three-dimensional polycationic network and abundant amino groups of this natural polysaccharide, the hydrogel electrostatically anchored RBCMs while preserving their native fluidity and membrane-bound acetylcholinesterase conformation-overcoming a long-standing bottleneck in biomembrane-based material engineering. Integration of carboxylated multi-walled carbon nanotubes endowed the composite with efficient electron transfer capability without compromising biocompatibility. The resulting biomimetic interface retained 85.8% of its initial electrochemical response after 7 days of continuous operation and enabled sensitive detection of organophosphate pesticides in real agricultural samples (apples, oranges, and tomatoes). This work established chitosan hydrogel as a versatile bio-based platform for constructing stable biomembrane composites, expanding the application scope of natural polysaccharides in functional material design for environmental monitoring.

     

    • Declaration of generative AI and AI-assisted technologies in the writing process
    At the time of writing this article, the author did not use generative AI or AI-assisted technologies. The author has carried out the necessary review and editing of the content and assumes full responsibility for the content of the published article.
    Author contributions
    Yusi Bu, Guoxi Xia, and Guoxiang Wang carried out the experiments and analyzed the data. Yusi Bu and Guoxi Xia wrote the manuscript. Minglei Zhang, Jiabo Wang, and Qiuhua Chen participated part of the experiments. Xiaolian Shi and Fang Sui designed the study and revised the manuscript. All authors have approved the final version of the manuscript.
    Ethical statement
    Animal studies was approved by the Biomedical Ethics Committee of Health Science Center of Xi’an Jiaotong University with ethical approved number XJTUAE2026-2146. During the experiment, the criteria were set by the Guide for the Care and Use of Laboratory Animals and the Guidelines of the Biomedical Ethics Committee of Health Science Center of Xi’an Jiaotong University.
    Declaration of competing interest
    The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
    Supplementary materials
    Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.jobab.2026.100283.
    Peer review under the responsibility of Editorial Office of Journal of Bioresources and Bioproducts.
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